Auto Repair Parts | Auto Parts

There ?re millions of automobiles riding along ?n the roads. Their repair ?nd maintenance i? crucial. Automotive equipment and auto lift repair parts ar? a v?ry important part of th??? two processes.

An auto lift ?s th? equipment th?t ?s u?ed to lift th? heavy vehicles well ?bove the ground. This ?s d?ne either t? transport them t? higher ground or t? do repairs underneath them. These lifts ??me in many forms l?k? in-ground lifts, runway lifts, four-post lifts, two-post surface mounted lifts, etc. These lifts operate ?n different ways ?nd th?? require different sets of maintenance drills. It ?? essential t? make ?ur? th?t th??e lifts are in good working condition ?nd maintained frequently t? avoid accidents ?nd injuries. The auto lift repair parts purchased ?h?uld b? of good quality and ?ble t? withstand wear and tear to ? large extent.

There ?re many suppliers who supply th??e parts. Many of them ?re ?lr??d? dealers ?n th? automotive tools ?nd equipments ?nd know exactly wh?t ?? required for their maintenance. Other automotive equipment generally supplied b? th?se companies include jacks, reels, tire changers, air compressors, lubricant pumps, battery chargers, etc.

It i? ?lw?ys wise to buy th?s? parts fr?m reputed companies ?nd brands t? avoid th? purchase ?f cheap and faulty parts. Ensure th?t the parts ?re industry approved and meet the industry standards. It i? n?t wise t? g? f?r th? cheapest stuff ?n this case. Quality i? m?r? important th?n price here.

An important point t? remember i? t? ensure that th? repair work ?? carried ?ut b? a well trained technician who ?s experienced in the field. He will n?t onl? do ? good job ?n making th? repairs but w?ll ?l?? b? able to give sound advice r?gard?ng maintenance.

Repairing the auto lift is a mu?h bett?r option th?t buying ? n?w on? for sev?ral reasons. For on? thing, n?w equipment ?s very costly. It is mor? feasible t? do th? repair work with auto lift repair parts. Another thing ?s th?t ?t ?s ?o?s?bl? to store ? f?w spare parts along w?th car parts in th? garage.

This makes th?m easily accessible ?nd saves ? lot ?f time spent on ordering ?nd waiting for delivery. It al?? beats buying a n?w machine th?t would t?k? to time to get delivered and set up. It als? helps if th? parts are replaced fr?m time to time, bef?re th? machine breaks down ?r ?n accident occurs due to wear ?nd tear. For this, regular checkups ??n b? arranged from ?n expert. One thing to note in ?ll thi? ?? th?t th? spare parts ?r? n?t ju?t one ?r tw? in number, but m?y go u? t? hundreds ?nd gett?ng th? h?l? ?f ? technician i? always ? good wa? to go in case of repairs.

Tags: air compressors, auto lift, automotive equipment, automotive tools, battery chargers, heavy vehicles, important point, sound advice, tire changers, uld

Source: http://www.yaids.org/120-auto-repair-parts-2.html

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The Home of Antiques ? Blog Archive ? Valuing Antiques: Hidden ...

For the antique novice, knowing or understanding the value of an antique is often difficult as there are many facets involved in the process.

While saying this, the opportunity to learn about the art of antiquing is more accessible than ever. The numerous television programmes dedicated to the antique market is impressive to say the least. The likes of the veteran Antiques Roadshow to the more recent Four Rooms and Flog It allows even the amateur enthusiast to pick up a few tips along the way. These shows prove to be as entertaining as they are informing as we witness images of shock, horror, elation and pride as antique hopefuls learn the history and value of their possessions.

The truth is, many of us virtually have an antique shop sitting idle in our attics, some may be more prestigious than others but none the less it is very likely you have ?junk? up there that is gaining in value as we speak.

According to Henry Sandon of the Antiques Roadshow (and notable authority on Royal Worcester porcelain) the modern definition of antiques is an item of fine quality and something people want to buy. A piece no longer has to be 100 years old to be an antique as it used to be. It can be an instant antique if it is of fine craftsmanship and caliber. The necessity for an antique to be of a certain vintage has itself passed its time. This is not to dismiss the worth in age when it comes to antiques, as usually things will increase in value as they mature.

it is worth taking the time to explore what treasures you may have in your own house. As well as the opportunity to profit from your belongings you are also detoxing your attic! You never know what information could be hidden beneath the dust and cobwebs, for example family heirlooms can offer up dates and geographical references that may otherwise be untraceable.

There are endless numbers of appraisers available to assist you with your evaluation. You may find some more helpful or knowledgeable than others so it is worth ?shopping around? to find the one which suits you best. There are some dealers who will specialise in specific items and others who will have a broad knowledge of antiques. If transport, weight or time is an issue for you, a second option is to source an online appraiser. This process is becoming increasingly popular as businesses become more reliant on their online customer. It also gives you a wider database of specialists as well as saving you time and transport costs. There are many websites offering this service, some more user-friendly than others but nonetheless they are convenient and for the most part the service is offered at a nominal price.

This entry was posted on Friday, February 3rd, 2012 at 12:15 pm and is filed under General. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.

Source: http://www.augp.org/valuing-antiques-hidden-attic-treasures-2/

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Good Ways To Overcome Your Asthma | baycityflyers

Other types of pieces received from the article author : Reference

Protect on your rrn opposition to pneumonia and bronchitis if you have asthma. The two of these sicknesses are associated to a lungs and explanation breathing to become toiled. As bad as that is for normal, safe particular person, it is a whole lot worse from an asthma sufferer because your lung perform is already minimal.

As said before at the start of this information will, far more youngsters nowadays than ever are actually being clinically determined to have asthma. There are several things that can be done to help better the possibility that your youngster will develop asthma. Implement the guidelines because of brief article, and assist make sure you childrens lungs remain healthy and strong.

BEST SITE

If youre an asthma patient, be sure to uncontrollably . folks who smoke, even if you are not a smoker alone. When cigarette ciggie is breathed in, particularly in ends in areas, your lung operate can certainly be significantly reduced which could raise your chances of affected by an episode.

Have you recently without having an inhaler when an asthma assault is coming on, check making a cool soda. The caffeine can actually open your airways and keep control of the asthma. Preferably keep your inhaler on you always, but this will help you find obtaining one single, attempt consuming a caffeinated beverage.

Make certain you dont have any food allergies should you have asthma. Nearly everybody find out the difficult way that theyre allergic to certain foods. Using an aversion also can consequence your asthma since your breathing can be reduced. Make certain to go to the er if you believe you might be using an allergic attack to edibles.

To Learn More Hope to retain yourself at optimum health and fitness for the greatest asthma administration. Ensure you stay hydrated, get a lot of going to bed and employ frequently. This will keep your body and immune program robust and reduce the danger of a serious asthma assault and a visit to the e . r ..

If you find that you are in a dusty area, do not place on any sort of supporter. This will shift all of the dust all around, and can very easily result in an asthma invasion. If you possibly can free a window that would be better, though if none are it is advisable to just depart the room. Urged that you know how to make use of asthma medication accurately. You could uncover everything about your prescribed drugs. You have to know how to spend it and when, any prospective unwanted side effects and in what ways it handles your asthma. If you use a metered inhaler, find out how to accurately apply it. If you suffer from asthma, a great word of advice is to consistently just be sure you do your sunny-ups prior to a physically demanding regular exercise as well as your cool-downs right after the exercise. Undertaking both of these issues can help keep you from having a severe asthma attack for the duration of your exercise or right after it. Have your own looked over at least once one year for mold together with other spores. Plenty asthmatics, peculiarly children, will present their asthma exacerbated by contact with these allergens. Existing in a house full of mold spores can even bring about done asthma attacks to the stage of permanently damaging a kids respiratory method.

Related posts:

1. Awesome Asthma Suggestions Being That May Work
2. Awesome Asthma Suggestions That Are Proven To Perform
3. Asthma Tips That Can Change Your Life!
4. Guidelines Which Can Help You Relieve Your Asthma
5. Quit Anxiety Attacks From Destroying Your Daily Life
6. Discover Ways To Preserve Skin pores Healthy And Attractive
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Source: http://www.baycityflyers.com/health/good-ways-to-overcome-your-asthma/

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Apathy will be the legacy of Romney's carpet bombing - Le?gal In?sur ...

Mitt Romney had a strong win last night in Florida.? There?s no way to spin it otherwise, just as there was no way to spin Newt?s South Carolina win otherwise.

But at what cost?

Financially the cost was about $17 million for Romney and his SuperPAC, almost entirely on negative ads.? Of the $15 million in negative ads run by or for Romney, only one was positive,? a radio ad in Spanish run only 15 times.

Last night, Brit Hume described the win appropriately: ?He beat Newt Gingrich by bombing him back into the stone age? with negative ads.

Despite Romney?s apparently straight-faced?yet completely false?assertions that he tried to run a positive campaign and only went negative because Newt outspent him in South Carolina, Romney?showed himself to be devoid of the ability to inspire the conservative base.? Tellingly, turnout in Florida was down significantly from 2008; by contrast, in South Carolina turnout was up significantly.

As noted yesterday by William McGurn at The Wall Street Journal, Romney?s campaign toughness is not a toughness of message but of personal attacks:

?Those of us who believed that a primary fight would toughen Mr. Romney up have little to show for it. Far from sharpening his proposals to reach out to a GOP electorate hungry for a candidate with a bold conservative agenda, Mr. Romney has limited his new toughness to increasingly negative attacks on Mr. Gingrich?s character. It?s beginning to make what we all assumed was a weakness look much more like arrogance.?

Romney?s strategy of carpet bombing rather than inspiring may result in the nomination, but at a?heavy financial price which will leave him weakened in a general election.? A strategy which depends on outspending rivals several times over in each state is a self-destructive path, as Alex Castellanos noted?last night on Twitter:

Mitt Romney has about a week to turn FL into national momentum. or he?s trapped in tactical statebystate wars which will cost $100m.

Romney?s dependency on carpet bombing also is not a winning strategy in the general election where Obama will have more money.? As Mark Levin noted the other day:

? while Romney can swamp his Republican opponents by 3 to 1 or more in every state with his spending advantage, Barack Obama will be raising more and spending more to beat him in the general election, meaning Romney?s financial advantage will be non-existent.

There were other costs to Romney?s victory, including the credibility of the conservative media.? If ever a thumb were pressed hard on the scale, it was in the past two weeks as Drudge turned his banner over to the Romney campaign linking to an endless regurgitation of anti-Newt media pieces planted by the Romney campaign.

We expect the conservative media to be biased against?Democrats just as we expect the mainstream media to be biased against Republicans.? What was?unexpected and disheartening, at least to those of us who are relatively new to Republican politics, was to find the conservative media biased against conservatives.? There?s no going back.

The other loss was to our history and purpose.

You know we have gone astray as a party?when even Michael Reagan had to come out and tell our presumptive nominee and his?political and?conservative media supporters?to stop lying about the Reagan revolution and Newt?s role in it.

We have in Romney someone who was willing to carpet bomb the history of the Reagan revolution and the conservative insurgency of the 1990s, movements he stood against when he ran for office in 1994 and 2002.

Are we any closer to a nominee?? Probably, although anything still could happen.

Are we any closer to defeating Barack Obama?? I think we are farther away than ever, as many Republicans, particularly those who joined in politics in 2009-2010, just don?t care anymore.

Unless something changes soon, apathy will be the legacy of Romney?s carpet bombing.

Update:? Turnout is even worse for Romney when you dig down county by county as George Mason Univ.?Prof. Michael McDonald did (h/t @ErickErickson):

In counties where Gingrich did better, Republican turnout was up over 2008. In counties where Romney dominated, turnout was lower.

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[Note: The post title was changed shortly after publishing to better reflect the conclusion.]

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Source: http://legalinsurrection.com/2012/02/apathy-will-be-the-legacy-of-romneys-carpet-bombing/

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WAHID'S METHOD ? THE CHARISMATIC & FRUITFUL GUIDELINE ...

Author speech:

Th?? article explicated th? analysis ?f business decisions ?? economic cost & benefit. If ??? find th? costs ?nd benefits fr?m th? investment- Y?? m??t b? clearly defined criteria t? b? used f?r evaluation against th? investment proposal. Th? criteria f?r m?k?ng ?n investment analysis ?f dealing benefits ?nd costs ?f ?n investment proposal, th??? benefits ?nd costs ?n m??t cases d? n?t take ?l??? directly, b?t th??? ?r? variable ?? th?t ??n b? generated f?r changeable periods.

On th? basis ?f m? experience, observed, & analysis, th?? article I h??? paid attention mainly ?n th? economic benefits achieved fr?m investing ?n ?nd operating a business. In th?? article, I h??? struggled t? expose ?n more specific terms w?th th? economic costs associated b? way ?f business decisions.

Throughout ?th? article I h??? tried talk ?b??t ?n greater details-th? cost ?f various types ?f capital employed ?n a business, examine h?w th?? cost ?? measured, ?nd ?n wh?t form ?nd f?r wh??h purposes th?? economic reality ?h??ld affect business d??????n m?k?ng.

Introduction:

Investment policies h??? given a n?w viewpoint t? th? ??rt ?f financial administration, Generally, I found th?t a few people knows th? g??d investment policy ?nd wh?n those people apply th??r knowledgeable strategy w?th th? investment usually th?? gain,, ?t ?? highly unlikely th?t without th? appropriate knowledge ?f investment policy a few people try t? r?n a business w?th a h?g? amount, b?t unfortunately m??t ?f th??? investors turn around fr?m th?? business w?th h?g? losses. ?ll decisions involving t? business investment fr?m th? analysis ?f investment ?n running capital such ?? cash, banks, accounts receivable, inventory ?nd investment capital represented ?n fixed assets such ?? buildings, land, machinery, technology etc. t? m?k? th? r?ght decisions th? financier h?? t? take ?nt? account elements ?f evaluation ?nd analysis ?? th? criteria f?r analysis,

meaning th? analysis ?f investment:

In m??t types ?f organizations ?r private companies, financial decisions ?r? focused ?r h??? a clear objective, ?th? maximization ?f assets b? th? utilities, th?? fact ?n th? present conditions, m??t refocus ?n a? maximizing wealth ?nd th? creation ?f ?business value?. Against th?? background ?n investment resources ?r? allocated ?nd results obtained fr?m th?m,

Meaning th? analysis ?f Operating d??????n:

Operating decisions th?t involve routine responsibilities. Such ?? ?l?nn?ng production ?nd sales, scheduling personnel ?nd equipment, adjusting production rates, ?nd controlling th? production Quality

Decisional framework:

Th? decisional framework I h??? discussed ?ll along strained th? interrelationship ?f investment, operations, ?nd financing. In m? experience observed th?t, over time, m??t management decisions cause cash movements ?n one form ?r another.

Th? dynamics ?f th? business system require th?t funds b? available ?t ?n? time temporarily ?r permanently fr?m a variety ?f sources, provided internally ?r externally. Key internal sources ?r? cash flows fr?m profitable operations ?r shifts ?n existing funds commitments.

Type ?f external sources ?r? borrowing ?r raising n?w equity. B?????? th? basic purpose ?f investing ?n, operating, ?nd financing a business ?? t? raise th? economic value ?f th? owners? bet over time, management decisions ?h??ld form economic value f?r th? shareholders b? generating ?ft?r-tax results th?t ?r? higher th?n th? cost ?f ?ll th? supporting capital inputs.

Investment Decisions

One ?f th? m??t vital long phrase decisions f?r ?n? business relates t? investment. Investment ?? th? Obtain ?r m?k?ng ?f assets w?th th? purpose ?f m?k? gains ?n th? future. naturally investment engaged b? financial wealth t? b?? a machine/ building ?r ?th?r asset, wh??h w?ll th?n give up returns t? ?n organization over a period ?f time

I th?nk th? first thing ?? t? identify wh?t ??? want. Y?? m??t know wh?t th? business prospect means f?r ??? ?nd wh?t ??? want t? achieve out ?f ???r investment. It ?? generally a g??d ?l?n t? h??? a pre-?l?nn?d profit level th?t acts ?? ?n object f?r ???r investment work. Th? g??d investor w?ll ?l?? take time t? recognize th? market th?t th?? ?r? trying t? pierce. D? n?t ???t rely ?n information ?r suggestions fr?m th? people. Y?? w?ll need t? g? ?nd see th? ????r?t? operation ?f th? business ?? th?t ??? ??n review whether ??? ?r? l?k?l? t? b? winning. Th? past ?f business investment ?? beset w?th ?t?r??? ?f people wh? jumped against schemes th?? d?d n?t know ?nd ?nd?d up paying a very heavy price

Following Solution ?f considerations ?n m?k?ng investment decisions ?r?:

1. Wh?t ?? th? scale ?f th? investment ? ??n th? company afford ?t?

2. H?w long w?ll ?t b? before th? investment ?t?rt? t? yield returns?

3. H?w long w?ll ?t take t? pay back th? investment?

4. Wh?t ?r? th? expected profits fr?m th? investment?

A g??d investor w?ll always look f?r t? administer ?nd shelter th??r investment. If ??? ???t ??t ?n investment project ?nd hope f?r th? best, ??? ?r? ?n a smooth slope t? financial r??n. Y?? w?ll need t? pay steady attention t? wh?t ?? happening t? ???r business b? requesting f?r management information ?nd evidence ?f growth. Th?t way smoothly ?f th?r? ?r? problems ??? w?ll know ?b??t th?m ?nd formulate a corrective strategy.

A? well established th?t l???t standards f?r investments h?d t? b? set high sufficient t? pay costs both f?r th? projects exact risk ?nd f?r th? chance loss ?f forgoing th? returns fr?m ?n? substitute uses ?f th? funds invested. Such alternative investments ?n th? company?s normal tricks ?r ?n n?w initiatives w?r? equally assumed t? sufficiently reimburse both shareholders ?nd lenders f?r providing th??r capital.

Cash flows connected w?th investment:

Wh?n creation ?n investment th? company expects a number ?f fixed cost ?nd production costs f?r a positive number ?f future benefits, th??? invention costs ?nd profit ?? called ?Cash Flow?, th?? components ?r? importance f?r investment d??????n

I recommended th?t th? company?s generally cost ?f capital, wh?n used ?? a minimum standard f?r th? economic attractiveness ?f investments, totally ?n person ?ll ?f th??? requirements, ?nd value w??ld b? ?r??t?d ?f a project?s cash flow performance exceeded th? company?s cost ?f Capital. Th? analytical methods directly include ?n? financing costs; r?th?r, th? cash outflows ?nd inflows ?? defined represented ?nl? investment outlays ?n th? one hand,

Rate ?f return required f?r investment d??????n:

Th? required rate ?f return ?? th? minimum rate ?f return th?t ?? n??????r? f?r ?n investment th?t w?ll b? established. In formative th?? rate m??t take ?nt? account ?ll internal ?nd external factors th?t influence th? investment d??????n.

M? statement ?n financial theory wh??h states th?t ?investors ?r? risk-aversive? takes gr??t implication ?n th? logic th?t, ?? th?r? ?? more risk involved ?n th? d??????n t? invest ?n a project w?ll require a higher give up wealth invested. Thus, th? expected return f?r ?n investment project depends ?n th? exact project risk assessment, taking ?nt? account th? risk free rate ?nd t? invest ?n th?? project. Th? aspects discussed ?effective tool ?n achieving th? proper financial management ?n th? d??????n t? rent business investment, b?t ?ll th?? m??t b? verified ?nd supplemented b? technical studies, math ?nd controls executed ?b? th? monitoring accountable f?r th? financial area ?f th? company.

Th? rules ?f a g??d investor ?r? n?t rocket science. Everyone ??n achieve ??m? level ?f success ?f th?? take th? time t? g? over th??r investment opportunities ?nd m?k? th? m??t logical business decisions best ?n th? information available ?nd th??r ?wn knowledge. Common sense d??? h?l? ?? well, especially ?f ??? ?r? dealing w?th people.

Operating Decisions:

Role ?f Operating Level ?f Management: Th? top level management divides ?b??t finance production, marketing, rules ?nd system f?r employees, process ?nd working methods. Th? middle level management collects n??????r? wealth ?nd services f?r th??r execution ?nd bottom level management implements th? rules process, methods ?nd programme shaped b? th? top level management. Th?? type ?f execution ?? associated w?th th? industrial regulation, continuity ?f activities ?nd m??t usage ?f resources. Middle level office supervisors ?nd bottom level jobbers, foremen ?nd workers ?r? connected w?th th?? work.

Decisions ?r? being implemented ?t bottom level ?nd f?r ?t? efficiency th? management?s method h?? t? b? followed. It includes following ?f working method ?nd working process. Due t? th? process ?nd methods, th? work ?f coordination between th? activities becomes effective ?nd ?n effective control wh??h ??n b? ??t ?n ?ll types ?f works. In short f?r th? decisions ?f efficiency, th? administrative process becomes ?n ?m??rt?nt ??rt.

Th? time prospect f?r operating decisions ?? generally shorter th?n th?t ?f th? typical business investment. h?w???r, operational funds movements, such ?? increases ?r decreases ?n trade credit both used ?nd extended ?nd swings ?n cash balances ?nd accruals ?? d???r?b?d ?n d? involve costs, both ?n th? form ?f out-?f-pocket charges ?nd opportunity costs. F?r case, a near-term d??????n t? take pay f?r discounts m?ght involve significant economic benefits wh?n weighed against th? cost ?f ?n? incremental borrowing essential t? take advantage ?f th? discount. Cash management decisions t? minimize bank balances ??n eliminate th? opportunity costs inherent ?n idle funds. In fact, th?r? ?r? myriad circumstances ?n wh??h near-term decisions ??n cause ?r eliminate th? cost ?f employing funds, ?? th??? decisions ?r? ?ft?n directly linked t? incremental sources th?t entail specific costs.

Effective decisions ?r? being full b? keeping th? present activities ?n mind ?nd th??r main aim ?? t? accomplish th? present objectives. Th??? decisions ?r? taken f?r th? getting ?f positive results b? fulfilling th? departmental objectives. F?r th?? th? departmental employees ?r? given training according t? th??r activities ?nd ?n effecting level?s personnel ?? given essential powers f?r th? same cases,

Above I h??? tried t? expose th? costs associated w?th obtaining financing ?nd compensating providers ?f different sources ?f funds, both short-term ?nd long-term, wh??h m??t b? considered b? management ?n m?k?ng ?n? financing d??????n. Obviously, using ?n? type ?f funds entails ?n economic cost t? th? company ?n one form ?r another. One ?f management?s obligations ?? t? expand a pattern ?f funding th?t both matches th? risk/reward profile ?f th? business ?nd ?? suitably modified t? meeting th? evolving needs ?f th? company. At th? same time, th? ??? ?f long-term funds entails meeting th? prospect ?f creditors, ?nd meeting ?r ?f possible exceeding th? potential ?f th? providers ?f equity funds, th? company?s shareholders.

Conclusion: Th? operative decisions ?r? different ?n nature ?n comparison w?th t? strategic decisions. Mostly th?? possess a special importance f?r achieving th? short term motives ?n framework t? th? internal situation ?f a business component

MHOHAMMAD WAHID ABDULLAH KHAN

S/O MOHAMMAD SAADULLAH KHAN

Dhaka, Bangladesh

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Mr. Mohammad Wahid Abdullah Khan ?? th? Project director ?f ?Max Textiles Ltd?.Mr. Wahid h?? b??n ?n accounting field ??n?? 1999. Prior t? th?t h? h?d completed over ten (10) years ?n various fields ?f Business l?k? ? Accounts, Finance, Internal & External Audit, project budgeting ?nd project costing related positions ?n ??m? ?f th? l?rg??t group companies & th? join venture companies ?n Bangladesh.

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H? consults w?th small- medium business owners ?nd services professionals, business consulting service ?nd project process. H? ?? m??t experience ?n Financial Risk Assessment, Financial analysis, Financial Advising ?nd Project Cost Analysis. H? h?? published more th?n 100 articles & case study ?n different international journals. Such ?? Business, finance, personal finance, international finance, auditing, Risk assessment topic ?nd performance & industrial related,

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Mr. khan?s m??t ????l?r articles ?? ??WAK? Model - Th? way ?f best solution f?r ?n organization internal audit process,( 1st,2nd,& 3rd ??rt) ?WAK? Model- f?r successful financial resource , ?Wahid khan?- cost analysis, Wahid theory ? th? key ?f dynamic series f?r successful financial consulting, Wahid techniques ? th? Significance ?nd dependability manner f?r Performance audit(1st,2nd,& 3rd ??rt) Wahid?s Opinion - non-conformity ?m?ng th? performance audit ?nd financial audit, Wahid?s view- Th? cogent task ?nd th? confront ?f financial/economic analysis ?n th? modern business d??????n m?k?ng , Wahid?s outlook- Th? Business Financial Analysis Sh??ld B? Included several required Documents w?th th? analysis report ?r ?l?n, WAHID?S JUDGMENT-d?ff?r?n?? strategic ?l?n ?? opposed t? ?n operational ?l?n , & PPBS Model, h? h?? consulted w?th more th?n 25 service & product companies,? ?n recent years Mr. khan h?? b??n spending m??t ?f h?? professional time f?r financial consulting , Mr. Wahid ?? th? owner ?f ?WAM? Associates ?nd ?WAK? business solutions;

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Experimental Drugs Do Battle Against Advanced Prostate Cancer (HealthDay)

TUESDAY, Jan. 31 (HealthDay News) -- Two new drugs, taken alone or potentially together, may boost survival for men with advanced prostate cancer, studies suggest.

The results were so promising that both trials were stopped early to make sure all participants could benefit from the drugs.

Men enrolled in both studies had what's known as "metastatic castration-resistant prostate cancers" -- tumors that had continued to grow and spread despite standard treatment aimed at lowering testosterone levels. (The male hormone testosterone is thought to feed prostate cancer).

The data were presented in San Francisco on Tuesday as part of the Genitourinary Cancers Symposium, sponsored in part by the American Society of Clinical Oncology (ASCO).

According to ASCO, more than 241,000 men in the United States will be diagnosed with prostate cancer in 2012, and 28,000 men will die from the disease.

Prostate cancer often spreads to the bone, but one of the new drugs, called radium-223 chloride (Ra-223), improved survival and delayed cancer-related bone problems in men with advanced, spreading tumors, the researchers said. The first in a new class of prostate cancer medications, Ra-223 delivers bursts of radiation to the bone, targeting the tumor.

The study included 922 men with advanced prostate cancer that had spread to the bone. The men were randomly selected to receive either Ra-223 plus best supportive care or a placebo along with similar care. Supportive care was aimed at alleviating the symptoms of the cancer, including pain.

The new drug seemed to help, boosting survival to an average of 14 months compared with just over 11 months for those on the placebo. Additionally, the average time to the first bone-break, fracture or need for radiation or surgery was significantly delayed among men treated with the new drug compared to their counterparts who received placebo -- from 8.4 months without Ra-223 to 13.6 months with it. The treatment also appeared safe, the research team concluded.

"The U.S. Food and Drug Administration said it will fast track [this drug], and I don't think additional data will be required," study lead author Dr. Oliver Sartor, professor of cancer research at the Tulane University School of Medicine in New Orleans, said at a meeting press briefing. He said the hope is that this drug will be available to patients in 2012. Ra-223 is being developed by Algeta ASA and Bayer Healthcare. The study was funded by Algeta ASA.

In a second trial, another experimental medicine, called MDV3100, appeared to boost survival by close to five months among men with advanced prostate cancer. This drug works by preventing male sex hormones (such as testosterone) from binding to receptors on cancer cells (the tumor needs these hormones to survive and thrive).

In the study, close to 1,200 men received either MDV3100 or an inactive placebo. Median overall survival was 18.4 months for men treated with the experimental drug compared with 13.6 months for those receiving placebo.

The new drug also reduced the risk of death by 37 percent compared to placebo, the researchers said.

Side effects included fatigue, diarrhea and hot flushes, and were generally considered mild, lead author Dr. Howard Scher, chief of the genitourinary oncology service and chair of Urologic Oncology at Memorial Sloan-Kettering Cancer Center in New York City, said at the press briefing. This drug is being developed by Medivation and Astellas Pharma. The study was funded by Medivation.

"This is very impressive and unprecedented," added Dr. Nicholas Vogelzang, chair and medical director of the developmental therapeutics committee of U.S. Oncology, a research network specializing in cancer clinical trials. He moderated the press conference announcing the new study results. "This is going to change the way we take care of patients who we see in the office," he said.

The real gold may be in combining the two therapies, the experts theorized. "These drugs are going to be used in sequence and we would expect the survival to be fairly dramatically pushed forward," according to Scher. "There will be a major bump up in the overall survival of this group of patients in the next two to three years."

Vogelzang agreed: "The synergistic benefit will have to be demonstrated, but it is very plausible that combining and sequencing these agents may add even more value than what we see here." He was a co-investigator on the Ra-223 study.

Findings presented at medical meetings are typically considered preliminary until they have been published in a peer-reviewed journal.

More information

There's much more on prostate cancer at the American Cancer Society.

Source: http://us.rd.yahoo.com/dailynews/rss/cancer/*http%3A//news.yahoo.com/s/hsn/20120202/hl_hsn/experimentaldrugsdobattleagainstadvancedprostatecancer

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Oil hovers below $99 after US crude supply jump (AP)

SINGAPORE ? Oil prices hovered below $99 a barrel Wednesday in Asia as investors eyed a jump in U.S. crude inventories and signs of sluggish economic growth.

Benchmark crude for March delivery was up 24 cents at $98.72 a barrel at midday Singapore time in electronic trading on the New York Mercantile Exchange. The contract fell 30 cents to settle at $98.48 on Tuesday.

Brent crude was up 20 cents at $111.18 a barrel on the ICE Futures Exchange in London.

The American Petroleum Institute said late Tuesday that crude inventories rose 2.1 million barrels last week while analysts surveyed by Platts, the energy information arm of McGraw-Hill Cos., had predicted an increase of 3.0 million barrels.

Inventories of gasoline fell 222,000 barrels last week while distillates added 970,000 million barrels, the API said.

The Energy Department's Energy Information Administration reports its weekly supply data later Wednesday.

Investors will be closely watching the latest U.S. employment data from January on Friday. The Conference Board said Tuesday that consumer confidence fell in January from December as Americans were more worried about their incomes, gas prices and business conditions.

The housing market also continues to struggle. Home prices fell in November for a third straight month in 19 of the 20 U.S. cities tracked by the S&P/Case-Shiller index.

"U.S. economic releases tilted toward the bearish side, and that these figures followed last Friday's negative GDP guidance conjured up images of some disappointing employment data," energy consultant Ritterbusch and Associates said in a report. "A difficult, choppy trading environment could be sustained well into February."

In other energy trading, heating oil rose 1.1 cents to $3.06 per gallon and gasoline futures were up 1.3 cents to $2.90 per gallon. Natural gas fell 5.5 cents to $2.45 per 1,000 cubic feet.

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/ap/20120201/ap_on_bi_ge/oil_prices

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